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Background: Caffeine is widely recognized as a potent ergogenic aid commonly used to enhance exercise performance and recovery. However, individual responses to caffeine can vary significantly, a variability that might be explained by genetic differences.Aim: This study aimed to investigate the influence of the CYP1A2 rs762551 SNP on the effects of caffeine (CAF) consumption on growth hormone (GH) and testosterone (TS) levels response to resistance exercise (RE) in male athletes.Materials and Methods: Thirty resistance-trained men (mean age 21.72±4.06 years, weight 77.31±14.07 kg, height 179.31±5.08 cm) participated in a randomized, double-blind, placebo-controlled, crossover study. They consumed either CAF (6 mg/kg) or placebo (PL; 6 mg/kg maltodextrin) one hour before performing a RE protocol including three sets with 85% of 1RM and two-minute rest. CYP1A2 genotyping categorized participants as AA homozygous ("fast" metabolizers) or AC heterozygous ("slow" metabolizers). GH and TS levels were measured by ELISA methods.Results: Repeated measures ANOVA showed significant differences in GH levels across time (F=10.94, P=0.000), with significant time-group (F=4.3, P=0.019) and time-genotype-group interactions (F=3.83, P=0.024). One-way ANOVA indicated significant differences in GH levels between CAF and PL conditions in AA individuals, but not in AC/CC genotypes. For testosterone, significant effects of time (F=14.88, P=0.000) and time-group interaction (F=3.197, P=0.045) were observed. Post-RE CAF supplementation significantly increased serum GH and TS levels in AA individuals compared to PL. Both CAF and PL groups showed increased serum hormone concentrations post-exercise.Conclusion: In conclusion, the study demonstrated that caffeine consumption significantly increased serum levels of growth hormone and testosterone in individuals with the AA genotype of the CYP1A2 rs762551 SNP. These findings suggest that genetic variations play a role in the hormonal response to caffeine, which may have implications for exercise performance and recovery strategies.

This research paper presented a comprehensive analysis of the literature on winter sports tourism, tracing its development over a span of 56 years. It was reviewed with bibliometric techniques with VOSviewer software. The extensive bibliometric analysis revealed emerging trends, notable research contributions, and key participants in the field. Prominent countries in this niche are Australia and Canada, while the Universities of Innsbruck and Waterloo, journals such as Sustainability Journal (Switzerland), and authors such as Falk and Muller, Peters, Scottwere have shown significant focus in this area. Therefore, the study highlights the increasing importance of this niche tourism sector, reflecting a surge of interest in recent years as indicated by the rising number of relevant research papers. The review also underscored how vital bibliographic studies are to comprehending the landscape of winter sports tourism. The findings provided trends, patterns, and a roadmap for prospective researchers, flagging the necessity of keeping pace with the evolving realities of winter sports tourism and establishing a valuable foundation for understanding and examining current trends and future developments in winter sports tourism. That will undoubtedly prove useful for both researchers and decision-makers in the field of winter sports tourism.