Introduction: Natural disasters are known as one of the most important factors in the destruction of human settlements. One of the key concerns for urban planners is examining how natural disasters affect human settlements, particularly cities. Earthquake is one of these natural disasters that has always threatened human settlements and can cause a lot of damage and casualties in a short period. Therefore, this study aimed to assess the vulnerability of settlements in District 2 of Tabriz, Iran, against earthquakes. Methods: This applied research was conducted based on a descriptive-analytical approach. The primary data of existing documents and maps were collected from related organizations. The analytical hierarchy process model and geographic information system software were used for data analysis. Findings: To determine the vulnerability of the texture of District 2 of Tabriz, such indicators as the distance from the fault, slope percentage, groundwater levels, building age, building materials, building quality, building density, number of floors, plot area, and land use were employed. Conclusion: According to the results, 35% of the region was in the high-risk and 25% in the very high-risk areas. In general, it can be said that most of the region (i.e. 60%) was in the area with a high risk of earthquake, and the area with very high risk was mostly in the northern parts of the region, while the southeastern parts of the region were located in low-risk areas
