INTRODUCTION: The location of Qazvin and Markazi provinces in high-seismicity regions has increased the probability of earthquake occurrence in these provinces. One of the most serious crises that threaten Qazvin and Markazi provinces is the post-earthquake fire which will be very probable considering the potential hazards. The present study aimed to identify the factors affecting the post-earthquake fire and present some strategies for pre-and post-earthquake preparedness in Qazvin and Markazi provinces. METHODS: In this descriptive-analytical study, the maps were produced using the Geographic Information System (GIS), and data collection sources were books, articles, and documents. Three main maps of risk, vulnerability, and crisis were prepared, and the analyses were performed by SWOT (strengths, weaknesses, opportunities, and threats) table. Thereafter, some practical strategies and policies were presented to achieve the intended goals. Strategies were developed for four programs to mitigate risk likelihood and vulnerability, manage fire, and reconstruct, along with development. FINDINGS: As evidenced by the obtained, the dispersion of some man-made factors, such as power transmission lines, gas stations, and high-risk industries, increases the likelihood of post-earthquake fires in both provinces. Furthermore, such geographical factors as scattered vegetation and location in arid climates increase the probability of fire spread. The final map of the crisis demonstrated that fires are more likely to occur in the center of Qazvin province and the north of Markazi province. CONCLUSION: Based on the results of the present study, the first step in regional planning and policy-making for the mitigation of fire hazards must be based on crisis maps and in harmony with subsequent hazards and damages. In this regard, to mitigate the risk of post-earthquake in these two provinces, the following measures are suggested: increasing safety in infrastructure, networks, facilities, industrial estates, and high-risk industries.