درخت حوزه‌های تخصصی

Background: Gene polymorphisms are related to athletic performance. Angiotensin converting enzyme gene polymorphism is essential in identifying talent and guiding adolescents to appropriate sports. Aim : The aim was to investigate the relationship between the angiotensin gene and endurance performance of novice adolescent wrestlers in Ardabil. Materials and Methods: Subjects were 15 Amateur adolescent wrestlers in Ardabil (age: 13.07±1.53 years, height: 164.60±10.68 cm, weight: 60.14±6.32 kg, BMI: 22.22±4.98 kg/m 2 ) with three-year wrestling. Chest and thigh muscle endurance, abdominal fat percentage and cardiovascular endurance, chest press, and squat muscle endurance were measured. ACE polymorphism was determined using tetra-ARMs polymerase chain reaction (PCR) and compared direct DNA sequencing in salivary samples. Chi-square and ANOVA were used to compare frequencies and their relationship with performance indicators. Results: ACE DD genotype frequency was higher in novice adolescent wrestlers, and there was a significant difference between ACE polymorphism frequency ( P =0.008). There was a significant difference between ACE genotype distribution with endurance performance of pectoral and triceps ( P =0.004) muscles, body composition ( P =0.0001), and Vo 2 max ( P =0.0001). There was a significant difference between body composition and Vo 2 max of Amateur adolescent wrestlers with ACE DD ( P =0.0001), ACE II ( P =0.0001), and between body composition and Vo 2 max with ACE II ( P =0.0001), ACE DD ( P =0.0001), and ACE ID ( P =0.0001). In body composition, ACE II was significantly higher compared to ACE DD ( P =0.0001) and compared to ACE ID ( P =0.0001). Also, in Vo 2 max, ACE II was significantly higher compared to ACE DD ( P =0.0001) and compared to ACE ID ( P =0.0001). Conclusion: Findings showed the superiority of ACE DD polymorphism and its relationship with the endurance performance of novice adolescent wrestlers in Ardabil. ACE DD polymorphism is probably essential in wrestler success. Other research with more subjects and other genes is important.

Background : Duchenne muscular dystrophy (DMD) is one of the most rampant x-linked recessive lethal genetic disease with prevalence of approximately 1 out of 3500-5000 newborn boys worldwide. DMD is mutations-induced in gene encoding dystrophin that prevent the production of the muscle isoform of dystrophin (Dp427m). Aim: This study aims to evaluate the impact of hydrotherapy on health-related quality of life and body composition changes, as well as how it affects on skeletal muscle strength in boys with DMD. Materials and Methods:  Eight boys, ranging from 6 to 12 years old with DMD were enrolled in this study. The patients were randomly assigned to either a hydrotherapy group as the intervention group (Group 1; n=4) or a non-exercise group as the control group (Group 2; n=4), to receive 12 sessions of a hydrotherapy program. The patients were assessed for changes in muscle strength in the lower limbs and back, left and right quadriceps, left and right-hand grip, LBM, SMM, and general mobility and balance, before and after hydrotherapy. Results : Significant improvements in general mobility and balance were observed, along with a significant increase in muscle strength and lean body mass ( P <0.05). Conclusion : This study suggests that hydrotherapy with a precise protocol of low to moderate intensity can improve general mobility and balance, increase muscle strength in the lower limbs and back, left and right quadriceps, left and right-hand grip, and LBM in patients with DMD. The increase in strength is accompanied by increase in LBM, which not only has implications for function but also has much broader impacts on the health-related quality of life in patients.

Background : Digit ratio (2D:4D) is a marker of prenatal androgen exposure that has been associated with behavioral parameters. Individuals with low 2D:4D are more aggressive and tend to engage in more physical activity. Aim: We examined the relationship between 2D:4D and physical activity, sensation seeking and aggression in mature and immature boys. Materials and Methods: The study population consisted of Mazandaran male students aged 9 to 17 years in 2019-2020. The sample was 218 healthy, cluster randomly selected boys (13.77±2.4 y/o) from three schools with no health issues. 2D:4D digit ratio, physical activity, aggression, sensation seeking were measured. Pearson correlation analyzed variable associations. Significance was considered at P ≤0.05. Results : Low 2D:4D ratio was associated with higher physical activity (r≈-0.27), sensation seeking (r≈-0.3), and aggression (r≈-0.21), during childhood and adolescence ( P <0.05). These relationships among right and left hand 2D:4D ratios with physical activity and sensation seeking remained consistent across maturity levels ( P <0.05). Only immature boys had a significant association between 2D:4D ratios and aggression (r≈-0.29, P <0.05). Physical activity was positively associated with sensation seeking (r≈0.25, P <0.05), but not aggression in mature and immature boys. Conclusion : Prenatal testosterone organizes boys' physical activity and behavioral parameters, influencing the later development of sensation-seeking and aggression and greater participation in physical activity. The study has limitations such as a small sample size and a self-report method for assessing aggression. Future research should focus on behavioral observation methods with larger sample sizes.

Background: Adropin is a newly identified bioactive protein that is important in energy hemostasis and vascular endothelial function. Aim : The purpose of the present study was to investigate plasma levels of adropin and nitrite/nitrate (NO), in elderly treated hypertensive subjects at baseline and follow-up after 6 weeks of high-intensity interval training (HIIT). Material and Methods: Forty-four elderly participants with treated hypertensives (age 61.09±5.82 years, 25 male and 19 female, BMI= 25.7±1.31 kg/m 2 ) were randomly assigned to either the high-intensity interval training (HIIT) or control group. The HIIT group received an intervention consisting of 10 intervals of 1.5 min at 85% to 90% of their heart rate reserve (HRR), separated by 2 min of rest at 50% to 55% of their HRR, in three sessions per week for a duration of six weeks. Plasma levels of adropin and NO were measured using enzyme-linked immunosorbent assay. The statistical analysis was performed by two-way repeated ANOVA to determine differences between groups and Pearson’s correlation coefficient to determine correlation. Results: The results showed that, following the six-week HIIT intervention, the plasma levels of adropin and NO significantly increased when compared to both control group ( P = 0.0016) and the baseline ( P = 0.0003) measurements. Peak oxygen consumption was increased after exercise training compared to the control group ( P =0.005). Δ adropin in the HIIT group showed a positive correlation with increased Δ NO (r= 0.707, P = 0.002) and Δ VO 2 peak (r= 0.836, P = 0.001), and a negative correlation with Δ DBP (r= 0.643, P = 0.025) and Δ SBP (r= 0.691, P = 0.013). Conclusions: The study findings suggests that HIIT can enhance both blood pressure and cardiorespiratory fitness. The observed increase in plasma level of adropin may have contributed to reduction of blood pressure by promoting nitric oxide production.