درخت حوزه‌های تخصصی

Background: The "athlete's heart" syndrome encompasses structural and functional cardiac adaptations to chronic exercise. These sports impose unique hemodynamic loads, potentially leading to distinct remodeling patterns. Objective: This study aimed to compare central cardiovascular adaptations, both structural and functional, in elite male athletes from basketball, volleyball, and handball to identify sport-specific differences. Methods: Thirty male athletes (aged 18-25; n=10 per sport group) participated in this cross-sectional study. All participants underwent comprehensive transthoracic echocardiography at rest and immediately following a maximal graded exercise test (GXT) on a treadmill. Key measured parameters included left ventricular (LV) dimensions, wall thickness, mass, ejection fraction (EF), stroke volume, and cardiac output. Data were analyzed using One-Way ANOVA or the Kruskal-Wallis test, with post-hoc analyses where appropriate. Results: While most parameters indicated a common adaptive athlete’s heart profile across all sports, significant sport-specific differences were found. Handball players exhibited a significantly higher heart rate post-GXT (180.11±9.45bpm) compared to both basketball and volleyball players (p<0.01). Furthermore, ejection fraction was significantly different between all groups at rest (p<0.05), with handball players also demonstrating a superior EF post-GXT compared to the other groups (p<0.05). A significant difference in left ventricular end-systolic dimension was also observed at rest between all three sports (p<0.001). Conclusion: The significant differences in post-exercise heart rate and ejection fraction, particularly in handball players, suggest that the pronounced upper-body and isometric components of handball impose a unique hemodynamic stress, leading to distinct functional adaptations. This underscores the importance of sport-specific interpretation of cardiac parameters in athletes.

Purpose: This study aimed to investigate the influence of genetic polymorphisms and metabolomic profiles on physiological adaptations to a 6-week High-Intensity Interval Training (HIIT) program in individuals with moderate fitness levels, addressing the variability in exercise response. Method: Thirty moderately fit adults participated in a supervised 6-week HIIT intervention. Pre- and post-training assessments included VO2max, lactate threshold, genetic profiling of key polymorphisms (e.g., PPARGC1A rs8192678) using PCR and next-generation sequencing, and untargeted metabolomic analysis via liquid chromatography-mass spectrometry (LC-MS). Statistical analyses involved paired t-tests, multivariate regression, principal component analysis (PCA), and partial least squares discriminant analysis (PLS-DA). Results: Significant improvements were observed in VO2max (p < 0.001) and lactate threshold (p = 0.004). Carriers of the PPARGC1A G allele showed greater aerobic capacity gains, accompanied by upregulation of PGC-1α expression. Metabolomic profiling revealed significant shifts in glucose and lipid metabolism pathways post-HIIT. Multivariate models identified interactions between genetic variants and metabolomic changes that predicted individual training responsiveness. Conclusion: Integrating genetic and metabolomic data enhances understanding of individual variability in HIIT adaptations and supports the development of personalized exercise prescriptions to optimize health and performance outcomes.