This study aimed to investigate the impact of the hospital information system (HIS) on nurses' satisfaction in Iranian public hospitals and to examine the moderating effect of computer literacy. The study population consisted of nurses working in public hospitals in Iran. A sample of 385 Iranian public hospitals was surveyed and a total of 1912 questionnaires were collected over 9 months. The analytical method used to empirically test the proposed hypotheses was the SEM technique using SmartPLS3. Results showed that all four variables of nurses' attitude, system quality, information quality, and service quality had significant positive effects on nurses' satisfaction with HIS. The findings also indicated that the effects of nurses' attitude, system quality, and particularly service quality increased on nurses' satisfaction with HIS by rising computer literacy, and only the effect of (computer literacy × information quality) was not significant on satisfaction. The use of FIMIX, CTA, and permutation test analyses is the innovation of the analysis.
