Purpose: The general aim of this study was to present a knowledge commercialization model based on teaching-learning in Mazandaran Islamic Azad universities. Methodology: The present study was applied in terms of purpose and descriptive-survey type in terms of method. The statistical population of this study included all faculty members of Mazandaran Islamic Azad Universities, which comprised 1537 individual. Using stratified random sampling, 308 individuals were selected as sample. To collect the data, a researcher-made knowledge commercialization questionnaire with 84 items and a researcher-made learning-learning questionnaire with 30 items were used. The face and content validity of the tools were confirmed by the experts and their reliability was calculated using the Cronbach's alpha coefficient for the knowledge commercialization questionnaire (0.89) and the teaching / learning questionnaire (0.85). Structural equations were used to analyze the data. Findings: The results showed that learning-learning has a positive and significant effect on knowledge commercialization, and the knowledge commercialization from learning-learning receives a direct and significant effect with a coefficient of 0.785. The fit of the proposed model was also suitable. Conclusion: knowledge commercialization is a process of transferring and transforming knowledge generated in research centers into a variety of business activities.