Purpose: Considering the importance of cancer in human societies and its negative effects on human body and psyche, the aim of this study was to compare the efficacy of Acceptance and Commitment Therapy and Schema Therapy on resiliency of breast cancer patients in East Tehran Medical Centers. Methodology: This study is a pilot study with single stage cluster sampling method. We selected 150 patients with breast cancer in East of Tehran. The Connor-Davidson Resiliency Questionnaire was presented. Forty-five subjects were randomly selected and divided into three groups of 15, consisting of two interventions and one control group, 12 sessions of group schema therapy and 12 sessions of acceptance-based therapy, each session lasting 90 minutes. Each intervention was performed twice a week for 3 days. At the end of treatment all three groups were tested. Findings: The finding showed that there is a significant difference between the experimental group under the influence of Acceptance and Commitment Therapy and Schema Therapy in post-test resiliency. F (1.41) = 530/35. Conclusion: The results showed that schema therapy is more effective on resiliency than, Commitment-Based and Acceptance.