Purpose: The purpose of this study was to investigate the design of a model based on the impact of information technology on the empowerment components of professors with mediating role of social resilience in the Payame Noor University of Mazandaran province. The research method was descriptive-correlational. Method: The statistical population of this research included all professors (scientific and invited) in Payame Noor University of Mazandaran (2539 people). In this study, 280 people were selected as the sample from three branches of Mazandaran Payame Noor University using randomized cluster method. Three standard questionnaires used as the measurement instruments in this research were Ghasemi’s information technology questionnaire, Spreitzer’s empowerment questionnaire, and Connor and Davidson’s resilience questionnaire. In the descriptive statistics part, plotting charts and calculating the statistical indices were used to describe the hypotheses. Structural equation modeling test was used to analyze the data. The data were analyzed using SPSS22 and Amos software. Results: The findings of this research indicated that the design of the model based on information technology influences the empowerment components of professors with mediating role of social resilience in the Payame Noor University of Mazandaran province and all the paths of the effect of the exogenous variables on endogenous variables and endogenous variables on exogenous variables are significant at the level of a = 0.05. Also, all direct and total effects of the endogenous and exogenous variables were significant (p0.05), and all indirect effects of the exogenous and endogenous variables on the endogenous variables were significant. In the final model of information technology and faculty empowerment variables, the highest path coefficient was for the path from information technology to faculty empowerment (0.72) and then from the components of faculty empowerment to resilience (0.71). Conclusion: Information technology and mediating empowerment components have a resilient effect on empowerment components and have shown their mediating role well.