Purpose: Entrepreneurship is the basis and foundation of successful economy and a hope for developing economic systems. Nowadays, engineering students must become engineers with entrepreneurial attitude. Unemployment of graduates of higher education is one of the recent problems of many countries of the world and one basic issue of higher education is development of factors affecting entrepreneurship in graduates. Method: In terms of method, this study is a descriptive study and in terms of purpose, it is an applied research and is also a qualitative study in terms of data. Data collection instrument is semi-structured interview and to determine sample size, purposeful sampling is used because of considering quality of data from sampling to theoretical saturation. Result: Academic experts and entrepreneurship lecturers and faculty members in relation with entrepreneurship and industry are selected and after the interviews, the data analysis is done through open and axial coding. Discussion: Hence, 15 factors affecting entrepreneurship of students are classified including education, research, motivation and entrepreneurial capacity, attitude, personality, information technology, management support, environment, entrepreneurship skills, culture, family, entrepreneurship lesson, commercialization and infrastructure.