Purpose: The purpose of this study was to investigate the relationship between social capital and quality of life with job satisfaction of teachers. Methodology: The present study was a descriptive correlational one in terms of purpose and method of data collection. The target population of this study was the teachers of Tehran city in 1998-99. 180 individuals were selected through multistage cluster random sampling. Data were collected using the Gannon Job Satisfaction Questionnaire (1981), Nachapithe and Guchal Social Capital Questionnaire (1998), and the World Health Organization Quality of Life Scale (1996). Findings: The results showed that social capital and quality of life had a significant positive relationship with teachers' job satisfaction. Also, structural capital, communication capital and cognitive capital and quality of life significantly predicted 48% of teachers' job satisfaction (P <0.05). Conclusion: The results of the study showed that social validity and validity, which are the major components of teachers 'social capital, determine the quality of life and will lead to teachers' job motivation and job satisfaction.