Purpose: The aim of this research was to determine the effectiveness of multidimensional spiritual education on happiness and responsibility of male Students. Methodology: The present study was semi-experimental with pre-test and post-test design with a control group. The research population was eighth grade Male Students of Imam رضا school of Mashhad city in 2017-18 academic years. Totally 40 students were selected by a purposive sampling method and randomly assigned into two equal groups (each group 20 students). The experimental group received 10 sessions of 80-minute multidimensional spiritual education and the control group didn't receive training. The research tools were Oxford happiness questionnaire and responsibility subscale of California psychological inventory. Data were analyzed by independent t-test and multivariate analysis of covariance methods in SPSS version-21 software. Findings: The findings showed that in the pre-test there was no significant difference between the groups in terms of happiness and responsibility (P>0.05), but in the post-test, there was a significant difference between them (P<0.05). Then, multidimensional spiritual education led to increasing happiness (F=11.79, P<0.001) and responsibility (F=5.36, P<0.025) in male Students. Conclusion: The results indicate the effectiveness of multidimensional spiritual education on happiness and responsibility. Therefore, it is recommended that counselors and therapists use a multidimensional spiritual education method along with other educational methods to improve psychological characteristics, especially promotion happiness and responsibility.