Effects of two selected resistance exercises and recreational sport activities on microRNA-148a expression and cardiometabolic risk factors of children with type 1 diabetes(مقاله علمی وزارت علوم)
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Background: Metabolic diseases such as type 1 diabetes is considered the most important threat factor for cardiovascular complaint. Although the pathological mechanisms underpinning the development of T1D are delicate to define, better understanding of the molecular aspects is most important to identify new remedial targets.Aim: Evaluating of the effect of two selected resistance and recreational sport activities on microRNA-148a expression and some biomarkers in children with type 1 diabetes.Materials and Methods: Twenty type 1 diabetic children were assigned randomly to resistance exercise (RE), (n=10, age=12.6 years), and recreational sport activities (RSA), (n=10, age=12.4 years) groups. Participants engaged in an 8-week exercise training, 3 sessions/week. The miR-148-a, HbA1c, glucose, insulin, and HOMA-IR levels have been assessed before and after exercise interventions.Results: Following the exercise interventions, the concentration of miR-148-a exhibited a non-significant increase in both groups. Nevertheless, no significant differences were noted in the reduction of insulin resistance or in the levels of insulin itself (P≤ 0.05). The level of HbA1c decreased but the cardio-respiratory endurance of subjects increased.Conclusion: Both the resistance and recreational sport activities were effective to improve in cardiorespiratory fitness, diabetic markers, and miR-148a changes that seem to be indicative of the pathological status of type 1 diabetic children.