Purpose: Academic buoyancy is one of the effective variables in the academic field and learning environment of students. Therefore, the objective of this research was to design the academic buoyancy model based on life expectancy with the mediation of happiness in female high school students in Hamedan city. Methodology: The methodology of this research was correlational and SEM. The statistical population included all female students of the second secondary school in Hamedan city, and the statistical sample was selected based on the number of items used in the questionnaires as 370 people with the multi-stage cluster sampling method. Academic buoyancy (Hosseinchari and Dehghanizadeh, 2013), life expectancy (Hallajian, 2019), and Oxford happiness (Argyl et al., 1989) scales were used to collect data. For data analysis, a structural equation test was used in the PLS-3 software environment. Findings: The results showed that life expectancy has a direct and positive effect on academic buoyancy (β = 0.36, p <0.01) and happiness (β = 0.46, p < 0.01). Happiness also has a direct and significant effect on academic buoyancy (β = 0.34, p<0.01). Also, happiness has a significant mediating role in the relationship between life expectancy and academic buoyancy (β = 0.16, p<0.01). Conclusion: since life expectancy creates a more positive atmosphere, it can be effective in increasing the feeling of happiness, and happiness creates buoyancy in the academic environment, followed by an increase in academic buoyancy.