Resistance is a concept that has been raised at different times and considered by many analysts from different angles. Islamic Republic of Iran’s resistance Policy Making is a method for foreign Policy analysis. Iran’s Foreign Policy is based on Policy Making. The Indexes of Islamic Republic of Iran’s resistance Policy Making in Foreign Policy is Cooperative method and interactive process with regional and international actors in environment crisis. Iran’s foreign policy is related and accordance with Identity and Revolution a thought on international relations.This article uses the descriptive method of analyzing and using library resources and information to answer the main questions of the article. What is Iran's strategic policy towards the American regional clients and what is the role of resistance in this process?The results show, the content and orientation of resistance policy making is based on regional competitive approach. Each kind of resistance Policy based on environmental competitive controls structural, identity, cultural and ideological differences and changes Islamic Republic of Iran’s resistance policy making have be seen in different issues especially resistance diplomacy and environmental security making in competitive regional policy.