The current article aims at studying the elements of continuity and change in Iran’s foreign policy toward the Nagorno-Karabakh crisis during Seyyed Mohammad Khatami, Mahmoud Ahmadinejad, and Hassan Rouhani’s administrations. It tries to answer the question as to which factors have contributed to continuity and change in Iran's foreign policy toward the Nagorno-Karabakh crisis between 1997 and 2018? The article shows that although the principles of Iran’s foreign policy toward the South Caucasus and the Nagorno-Karabakh crisis have not changed during this period, the changing role of the external powers – Russia and the West – as well as different foreign policy priorities defined by the three administrations, have caused changes in Iran's approach to this issue. An inductive approach and a qualitative research method has been used in this article. Official documents, news and research articles have been used as the main sources of data in this article.