درخت حوزه‌های تخصصی

Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine. Aim : The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer. Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P <0.05. Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups ( P <0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups ( P <0.05). Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.  

Background: COVID-19 transmission in team sports is common, but it's uncertain if face masks impact handball players' performance. Aim: This study investigated the effects of wearing surgical face masks during handball exercise for four weeks on athletic performance. Materials and Methods: Thirty-four adolescent handball female players and 17 trained females as the control group were selected in this study. Players were divided into two groups: the mask group (n= 17; age: 12.63±0.67 years, BMI: 20.61±1.19 kg/m2) and the unmasked group (n= 17; age: 13.45± 1.03 years, BMI: 21.08±1.46 kg/m2), who underwent 4-week training with and without face masks, respectively. Performance tests were conducted before and after the training program, which include: countermovement jump (CMJ), squat jump (SJ), 10m, 20m, and 30m sprint, medicine ball throw, and Yo-Yo Intermittent Recovery Test Level 1 (Yo-YoIRT1). Results: After four weeks, both mask and unmasked groups showed significant improvements in CMJ, SJ, 10m, 20m, and 30m sprint, medicine ball throw, and Yo-YoIRT1 (P≤ 0.05). Conclusion: This study concludes that adolescent handball players can safely use face masks during physical activity without experiencing negative effects on their athletic performance.