The integrative process of cooperation between countries in a region is an increasing discussed issue in area studies. The reality of international politics today is based on how regions are inter-connected. International trade or other international regimes are indeed the developed models of integrated structures and processes among countries within a region. Therefore we are facing with a regional extended version of some regimes at global level. Organization of Islamic Cooperation as a regional and intraregional organization is the main theme of current research in which will be analyzed and compared with Association of Southeast Asian Nations to understand dynamism of regional cooperation and progress in economic and security issues. Comparative regionalism is our tool to understand the two organizations and an analytical framework for comparison.