The question from the mission of architecture and its relationship with human as the artist or the audience, without addressing to the reality issue and the manner of cognition is not possible. As a human phenomenon, architecture is a product of human awareness on various aspects such as scientific, engineering, and artistic aspects. Therefore, clarifying the nature and the manner of awareness, cognition and the methods and tools, can contribute to understand the art work. In continue the manner of advent and perception of wisdom in the Islamic architectural work would be analyzed. The research method is logical reasoning. Therefore, initially the Islamic worldview is posed based on the transcendental philosophy as the last and most important and major Islamic philosophy evolution, this approach is a strong system with logical method and has a strong theoretical transparency in order to understand the definition of components such as ontology, anthropology, epistemology and cosmology. After explaining principles of mental structures according to proposed Islamic worldview, the manner of emergence of the architectural work by creator of the work and how it is perceived by the audience and the work relationship with reality, based on the quad and quintet causes, ultimate and in instance, nominative, substantial, formal which have been considered in the formal position of discussion. The manner of Islamic architecture as nominative cause and the advent of thought and imagination, as the ultimate and in instance cause and actuality of the mass and the space, as substantial causes in the form of the face of place as formal cause is the purpose of this research. The manner of creation and perception of the work and the manner of presence and the advent of reality in architecture are exامینed by determining nature and the manner of emotions, perceptions and cognition. The most important result of this study is to address the main mission of architecture as the creator of the cognition factor.