محسن غفرانی

Background: In addiction field, there is more attention on men than women, while women are more vulnerable to addiction. Because of the importance of women in the family foundation, we decided to investigate this subject. Purpose: This study aims at the effect of 8-weeks of combined training with methadone on cardiovascular inflammatory markers fibrinogen and CRP on addicted women. Method: This study accomplished as a semi-experimental research. 24 addicted women were randomly selected as samples from Zahedan Mohabbat addiction Camp that divided in two groups of methadone (N= 11) and methadone/ exercise (N= 13) by the same variables such as age, BMI, type and duration of drug withdrawal. The protocol of combined exercise was included of aerobic added to strength training; also methadone was taken according to the camp instructions, too. Blood sampling, pre and post 8 weeks exercise were directly collected from anterior veins of samples and the levels of plasma fibrinogen and CRP were measured in lab. To compares of the pre and post tests means for each group as well as both groups, paired and independent t-test via SPSS software version 24 were used, respectively. Statistical significant level was considered PResults: The results showed that CRP values in both groups decreased significantly (methadone: p <0.05, T=-2.21 and methadone/ exercise p <0.05, T=-2.63). Also, plasma fibrinogen values in both groups increased significantly (methadone: p <0.05, T=5.03 and methadone/ exercise: p <0.05, T=4.21). Also, there were no significant difference between post-test’s levels of CRP and fibrinogen between methods (P>0.05). Conclusions: It has suggested that the method of methadone/ exercise might be used as such as methadone method by the same results on plasma fibrinogen levels and CRP for withdrawal addiction women.

Background: Vaspin is an adipokine secreted from fatty tissues that has serious effects on adipose tissues, muscles, liver, and inflammation. Purpose: The study aimed at determining the effects of 8 weeks of combined training (resistance and endurance) on the serum vaspin level in obese girls. Method: The examinees consisted of 25 obese female students (BMI> 30) from Sistan-Baluchestan University in 2016-17 academic years who voluntarily participated in the research. Samples were divided randomly into two groups: Training (n = 13) and Control (n = 12). Combined training group had both resistance training (5 stations of foot press, Lat pulldown, biceps curl, knee flexion and knee extension for 75-70 minutes) and; endurance was running on the treadmill; in the 2 first weeks, with 60% HR<sub>max for 25 minutes, in the 3-6 th weeks with 75-65% HR<sub>max for 35 minutes, and in the 6-8 th weeks with 75 -85% HR<sub>max for 40 minutes, continuously, for 3sessions each week. Also 10 minutes at the beginning and at the end of the training were warm up and cool down for athletes. It should be noted that during this period the control group did not participate in any kind of sports activities. After receiving the consent forms, the examinees were given enough information regarding the research procedure and their blood samples were obtained in a standard position, collected in pipes containing EDTA, and centrifuged 24 and 48 hours before and after the first and last training sessions, respectively. The obtained plasmas were kept at -80 ° C and their serum vaspin concentrations were measured by ELISA method using the special Human Vaspin kit. To analyze the data, the paired and independent t-test and SPSS-21 Software were performed; the meaningfulness level p was considered to be less than 0.05 (p < 0.05). Results: Results showed that after 8 weeks of combined training, the vaspin levels, weight, BMI, WHR, and %BF decreased meaningfully in the training Group compared to the control Group (P <0.05). Conclusions: considering the meaningful vaspin reduction in this study, it seems that combined training (resistance and endurance) is beneficial to obese and overweighed people.

Background: In addiction field, there is more attention on men than women, while women are more vulnerable to addiction. Because of the importance of women in the family foundation, we decided to investigate this subject. Purpose: This study aims at the effect of 8-weeks of combined training with methadone on cardiovascular inflammatory markers fibrinogen and CRP on addicted women. Method: This study accomplished as a semi-experimental research. 24 addicted women were randomly selected as samples from Zahedan Mohabbat addiction Camp that divided in two groups of methadone (N= 11) and methadone/ exercise (N= 13) by the same variables such as age, BMI, type and duration of drug withdrawal. The protocol of combined exercise was included of aerobic added to strength training; also methadone was taken according to the camp instructions, too. Blood sampling, pre and post 8 weeks exercise were directly collected from anterior veins of samples and the levels of plasma fibrinogen and CRP were measured in lab. To compares of the pre and post tests means for each group as well as both groups, paired and independent t-test via SPSS software version 24 were used, respectively. Statistical significant level was considered PResults: The results showed that CRP values in both groups decreased significantly (methadone: P<0.05, T=-2.21 and methadone/ exercise P<0.05, T=-2.63). Also, plasma fibrinogen values in both groups increased significantly (methadone: P<0.05, T=5.03 and methadone/ exercise: P<0.05, T=4.21). Also, there were no significant difference between post-test’s levels of CRP and fibrinogen between methods (P>0.05). Conclusions: It has suggested that the method of methadone/ exercise might be used as such as methadone method by the same results on plasma fibrinogen levels and CRP for withdrawal addiction women.

Background: Vaspin is an adipokine secreted from fatty tissues that has serious effects on adipose tissues, muscles, liver, and inflammation. Purpose: The study aimed at determining the effects of 8 weeks of combined training (resistance and endurance) on the serum vaspin level in obese girls. Method: The examinees consisted of 25 obese female students (BMI> 30) from Sistan-Baluchestan University in 2016-17 academic years who voluntarily participated in the research. Samples were divided randomly into two groups: Training (n = 13) and Control (n = 12). Combined training group had both resistance training (5 stations of foot press, Lat pulldown, biceps curl, knee flexion and knee extension for 75-70 minutes) and; endurance was running on the treadmill; in the 2 first weeks, with 60% HR_max for 25 minutes, in the 3-6 th weeks with 75-65% HR_max for 35 minutes, and in the 6-8 th weeks with 75 -85% HR_max for 40 minutes, continuously, for 3sessions each week. Also 10 minutes at the beginning and at the end of the training were warm up and cool down for athletes. It should be noted that during this period the control group did not participate in any kind of sports activities. After receiving the consent forms, the examinees were given enough information regarding the research procedure and their blood samples were obtained in a standard position, collected in pipes containing EDTA, and centrifuged 24 and 48 hours before and after the first and last training sessions, respectively. The obtained plasmas were kept at -80 ° C and their serum vaspin concentrations were measured by ELISA method using the special Human Vaspin kit. To analyze the data, the paired and independent t-test and SPSS-21 Software were performed; the meaningfulness level p was considered to be less than 0.05 (p < 0.05). Results: Results showed that after 8 weeks of combined training, the vaspin levels, weight, BMI, WHR, and %BF decreased meaningfully in the training Group compared to the control Group (P <0.05). Conclusions: considering the meaningful vaspin reduction in this study, it seems that combined training (resistance and endurance) is beneficial to obese and overweighed people.