After losing the Battle of Chaldiran, the Safavid administration had a difficult time in integrating the al-Tawaifi court system under the central authority. Feudalism of Shah Ismail was able to subjugate the local authorities and unify a portion of Iran's territory with the help of the Qizilbash force. Due to territorial and theological disputes, the Safavids and two Ottoman and Uzbek kingdoms engaged in several conflicts as a result of making Shīʿīsm as official faith in Iran. Following the Safavids' loss at Chaldiran, centrifugal (local) forces became more powerful and eclipsed the influence of numerous rulers. The Safavid era turned out to be significant historically. The study's findings indicate that the central Safavid government faced a significant challenge in concentrating power following the defeat at Chaldiran, and this challenge persisted with only a minor variation during later kings until the end of Mohammad Khodabande's reign.