Background: Ethical principles applied in organizations can broaden individual and corporate priorities beyond profit and shareholder enrichment. Ethical factors may influence leaders to make sound decisions to protect the organization from unethical behavior. The present research seeks to investigate the effects of managers' professional ethics on decision-making strategies regarding the role of the capacity of information management systems capacity in the managers of Islamic Azad University, Mashhad Branch. Method: The present study is a descriptive-comparative study. The population in this study is determined to be a group of managers of Islamic Azad University, Mashhad Branch concluding 111 individuals. Data collection was conducted through questionnaires of professional ethics, decision-making strategies, and information systems capacity. The sample size was obtained utilizing the Cochran's formula and the data collection was performed using simple stratified random sampling method. SPSS and Smart PLS were used to analyze the statistics and the structural equation modeling method was used to answer the research hypotheses. Results: The results showed that managers’ professional ethics has an impact on decision-making strategies, but information systems capacity does not modify the influence of managers’ professional ethics on decision-making strategies. Conclusion: Professional ethics affects decision-making strategies at Mashhad Islamic Azad University. Therefore, observance of ethical issues in the organization, especially in dealing with managers with employees is a need and respect should always be considered so that the employees feel more committed to their work and organization.