Background: Nowadays, one of the aspects of power and distinction of organizations is the enjoyment of desirable organizational culture. The organizational culture of each complex is the full representation of the organization, which shows the inner and outer face of the commitment of the employees to principles of ethics. Professional ethic is related to values and norms and is one of the most important issues that have been considered in different areas of the modern world. Therefore, the purpose of this research is to predict professional ethics with respect to organizational culture. Method: The research method is descriptive-correlation. The statistical population consists of 230 people who are the employees of Islamic Azad University, Mashhad Branch and the sample size was determined 103 people using Cochran formula with 95% confidence level and a Stratified Random Sampling method. Standard questionnaires were used to collect data. The obtained data were analyzed using Smart PLS and SPSS structural equation modeling. Results: Findings of the research indicate that the components of perceived organizational culture have a significant effect on the dimensions of professional ethic including accountability, honesty, justice, fairness, loyalty, respect for others, competition, sympathy, respect for values. Also, based on the multiple regression analysis, components of organizational culture predict all dimensions of employee ethic and finally, it can be concluded that the professional ethic of the employees are at a favorable level. Conclusion: The results of the present research illustrate that the components of organizational culture predict the dimensions of professional ethics of the employees.