Mass and indiscriminate killing has been condemned by all civilized nations, and yet, Weapons of Mass Destruction -WMD- exist in the arsenal of the world military powers. This paper delves into the effects of the WMD on the two main concepts of justice and peace at different war doctrines and reviews the main paradigms over nuclear weapons prohibition in relation with the international security. I examine key concepts of the three main schools of thought in International Relations -IR- to assess their consequences on the feasibility of cooperation for a WMD free world. With elaborating on how to team up basic assumptions in international relations and harmonizing different national viewpoints regarding abandonment of these weapons to uphold peace and justice globally, and prohibit WMD in the Middle East; this study suggests that a balance approach to enhance exchange of relations rather than denial, sanction and isolation is essential to abandon WMD.