Though personality factors and language learning strategies have been extensively examined over the last three decades, we have witnessed a dearth of studies zooming in on these issues from a cultural perspective within the Iranian context. Additionally, few studies have investigated whether personality factors can predict the choice of language learning strategies in an Iranian EFL context. In response to these shortcomings, a group of Iranian EFL learners were administered Big Five Factors Inventory (Goldberg 1993), Strategy Inventory for Language Learning (Oxford 1990) and Metacognitive Awareness of Reading Strategies Inventory (Mokhtari & Reichard 2002). It was found that the Iranian EFL learners could highly or moderately used the language learning strategies. It was also found that personality factors could predict the use of some language learning strategies in the cultural context of Iran. It was concluded that cultural norms could modulate some aspects of personality and language learning strategies and consequently some aspects of personality could predict the choice of particular language learning strategies. An awareness of learners’ personality factors and the way they shape the language learning strategies can contribute to successful language learning and optimally help teachers devise appropriate teaching techniques.