The interactions and linkages between urban centers and peripheral settlements are increasingly recognized as key factors in the process of social, economic and environmental changes in peripheral settlements. Despite this, most practices are implicitly based on a dichotomous view of population and activities in urban and peripheral area. This paper presents that how interactions between urban centers and peripheral settlements include spatial linkages (flows of goods, money, capital, people, information, production, technology and wastes) affect on peripheral changes. The interactions and linkages between the urban centers of Qazvin and 20 peripheral settlements there show that the effects of this interaction upon the peripheral settlements have included more inorganic effects. Urban and peripheral development need to be considered as complementary process rather than competing activities for the limited resources. The benefits of such an integrated approach will outweigh of the costs.