Although for a couple of centuries empiricism was prevalent in physics circles , the development of various schools of philosophy of science, during the second half of the twentieth century, made it clear we do not encounter nature with empty minds and that scientists always use some assumptions in their scientific work. In this article. We argue that metaphysical assumptions play an important role at various stages of science activity. But these assumptions are usually taken from various schools of philosophy or religions. Monotheistic religions can provide such principles. Thus, metaphysics works as a bridge between science and religion.