The purpose of this study is to investigate the role of marital satisfaction and marital intimacy of mothers in predicting anxiety and depression in female student in Zanjan city. This study is considered as a descriptive/correlational research. The statistical population studied in this study were all female high school students in the Zanjan city and their mothers. The sample size was calculated using Cochran's formula, 367 of 8160 people were selected by stratified cluster sampling. To collect data were used from ENRICH: Marital Satisfaction Scale (EMS) (Olson, 1989), Depression Anxiety Scale 21-Depression Scale, Marital Intimacy Scale, (Walker). Data were analyzed by regression analysis in SPSS 25 software. Inferential analysis was performed at a significance level of 0.05. According to the results, the average of marital satisfaction was at the moderate level, marital intimacy and depression and anxiety of children were at a low level. According to the results of stepwise regression, marital satisfaction and intimacy explain 0.42 of the variance of depression and 0.15 of the variance of adolescent anxiety. In general, according to the results of the study, as marital satisfaction and marital intimacy of mothers increase, depression and anxiety of girls decrease.