The present research was performed to evaluate the Iran-US relationships in 2029 from the Iranian Professors’ point of view. Investigations were perfumed via future studies in two parts: The first part is based on library studies, and the second part is questionnaire-based field surveys, with the acquired data analyzed using MicMac and Scenario Wizard software tools. Based on the results of the analysis in the MicMac software, a total of 20 driver forces for the Iran-US relationships were identified. Considering the driver forces as descriptors of the Iran-US relationships, the most significant driver forces were found to be the government institutions context followed by the relationship-interfering countries, the role of the two countries’ leaders, future of the international system, think tanks, lobbies and pressure groups, nuclear capabilities and missile program of Iran, the role of geography, and historical records of the relationships between the two countries. Based on the outputs of the Scenario Wizard software, five scenarios were identified, including highly favorable, favorable, moderate, unfavorable, and highly unfavorable, with the development of the Iran-US relationships under the moderate scenario being highly probable.