Objective: The main aim of this research was to investigate the effects of quality of life therapy on increasing the coping ability with stressful situations, reducing anxiety and irrational fears in at risk workers of electricity distribution companies in Isfahan. Method: This research was of semi-experimental with pre-test, post-test and follow-up with the control group. Population were consisted of 250 at risk workers of Isfahan Electricity Distribution Company. Five people were randomly selected from each unit, and a total of 40 people were randomly assigned to the experimental and control groups. The experimental group participated in 90 minutes’ sessions of quality of life improvement training for 8 weeks, held at the New Technology Park of Isfahan Electricity Distribution company. Experimental group was compared with a waiting control group. measurement tools were consisted of Endler and Parker Coping Inventory for Stressful Situations (CISS) and Mental Disorders Symptoms Checklist (SCL-90-R) that were administered on at risk workers in the pre-test, post-test and follow-up phases. Repeated measure analysis of variance was used to analyze the data. Results: Data analysis showed that the intervention sessions had a significant effect on the all scales of coping with stressful situations, anxiety and irrational fears in the experimental group in the post-test and follow-up stages. Conclusion: The results indicate that psychotherapy based on improvement of quality of life was effective on tranquility, mental health and the quality of life of at risk workers in Isfahan electricity distribution company.