Development of modern economy without private sector and high vigilance entrepreneurs is vital to identify opportunities and use of opportunities around the world. In this regard, identifying the influencing factors on emergence and development of entrepreneurship culture can be effective to promote entrepreneurship in our country. For this purpose, the main issue in this study is to identify the elements of entrepreneurships making culture to support small and medium sized enterprises. To answer the question, the purpose of this study is to design a model for influencing factors on national entrepreneurship to support small and medium sized enterprises using literature review and experts opinions. To achieve the goal, Delphi Model was used. Delphi survey results showed reduction of bureaucracy in launching a business, raise the social status of entrepreneurs, social and economic justice, reform of popular culture and religious beliefs to work, reforming education and management structure in the country, government support, creating and the development of venture capital funds, targeted tax cuts, respect other people's capital, raising national security investment as factors influencing entrepreneurship in support of small and medium enterprises.