Objectives: The present study has investigated the role of orthodontic treatment on patient’s mental health, body image and oral health-related quality of life. Method: In this quasi-experimental study a sample of 90 patients referring to orthodontic clinics in the city of Kermanshah were selected using purposive sampling method and then they were assessed before and 6 months and one year after undergoing orthodontics via the “The Symptom Checklist-90-R” (SCL-90-R), “Multidimensional Body–Self Relations Questionnaire” (MBSRQ), and Oral Health Impact Profile (OHIP-14). Data were analyzed using one way analysis of variance. Results: patients reported less obsessive compulsion, hostility and paranoid ideation symptoms on (SCL-90-R), after six months and one-year treatment (P ˂ 0.05). In addition, the comparison of scores before and after treatment showed that there was significant difference in appearance evaluation and body areas satisfaction dimensions of MBSRQ (P ˂ 0.05). Also, there were significant different found on physical disability, psychological disability, social disability and total score of OHIP-14 before and after treatment (P<0.05). Conclusion: This quasi-experimental study highlights orthodontic treatment role on mental health body image and oral health-related quality of life in patients with dental problems.