Iran and the United States have experienced hostile and tense relations since the occupation of the U.S. Embassy in 1358. During this time, the White House has not given up on any attempt to change the government in Tehran. The main question is ‘What is the tremendous strategy of the United States to counter the Islamic Republic of Iran in the Biden era?’ The central hypothesis is the U.S. has two new strategies confronting Iran: de-geopolitics abroad and de-legitimacy inside. The present study aimed to analyze these two strategies. The results indicated that according to the teachings of Smart War, the U.S. has two goals for these actions; first, a sinusoidal and erosional process aimed at deprivation and discrediting of the Iranian political system in internal and external levels (de-legitimacy and surrender). The depletion of Iran's strategic and geopolitical capacity in the region to remove power tools from it (weakening to surrender or change the regime).