Objective: Drug addiction is one of the four worldwide crises of the third millennium, at the forefront of risks and societal ills, and one of the most severe challenges confronting today's societies, particularly ours. The purpose of this research was to assess the efficacy of mindfulness on drug craving, stress, and cortisol levels in Mashhad-based males who used crystal meth. Method: Pre- and post-tests with a control group were the sort of quasi-experimental study used. The statistical population comprised all males who used crystal meth, which was sent to the Ofogh Rah-e Sabz addiction treatment clinics in Mashhad, from which 30 participants were randomly assigned to the experimental and control groups using accessible sampling methods (15 people in each group). They answered the Holmes and Rahe stress questionnaire in addition to the Somoza et al. cravings questionnaire. And their urine was examined to determine cortisol levels. The experimental group got eight sessions of mindfulness treatment, whereas the control group received no treatment. Multivariate analysis of covariance was used to examine the research data. Results: The findings indicated that mindfulness lowered cravings and stress while increasing cortisol levels (p<0/001). Conclusion:According to the results, mindfulness-based interventions may be utilized with medical therapy for methamphetamine addicts.