Objective: The purpose of the present study was to examine the effect of lifestyle-based stress management program on emotional problems and life satisfaction in patients with myocardial infarction. Method: This research was quasi-experimental with pre-test, post-test and control group. The statistical population of this research consisted of all patients aged 40-65 years old with myocardial infarction who were under treatment at Kasra Hospital in Karaj in the first six months of 2019. The study sample consisted of 90 patients with heart attack who were identified among the patients and selected by targeted sampling method and randomly assigned to two experimental and control groups. Data were collected using the Depression, Anxiety and Stress Scale as well as the Satisfaction With Life Scale. The collected data were analyzed using the method of Multivariate analysis of covariance (MANCOVA). Results: Multivariate analysis of covariance showed that the lifestyle-based stress management program significantly reduced emotional problems and increased life satisfaction in the experimental group (p <0.01). Conclusions: The stress management program helped patients identify dysfunctional thoughts that trigger anxiety and depression and experience fewer emotional problems by feeling self-control, attention management, changing the assessment system and using cognitive strategies. Also, by identifying and correcting irrational attitudes and beliefs, the subjects were able to better cope with the physical effects of the disease or to deal with its negative psychological complications and have more life satisfaction. These findings have important implications for education and promoting mental health of patients with myocardial infarction.