Cognition of Countries backwardness especially developing countries is the subject of research and interest of many of thinkers from decade 1970 until now. Although most of Islam world countries are among the above group but a little researches are concerned especially on cultural challenges in these countries. Cultural crisis is including fundamental problems of Islam world that is of complicated dimensions and needs to more attention of Muslim thinkers. According to the intellectual, jurisprudential position and leadership of Imam Khomeini in Islam world, investigation of thinks and views of founder of Islamic revolution of Iran about this intellectual challenge assistance to cognition this situation. Purpose of this research is study views of Imam Khomeini about the cultural challenges of Islamic governments using the crisis theory of Thomas A. Spragens. findings of study shows that cultural problems such as Westernization, Separation, self-destruction, spiritual dependence, meaning and identity crisis, political and economic instability, intervention of foreign powers and cultural invasion and so on. A study of Imam's political thought about the cultural problems of the Islamic world shows that in Imam Khomeini's view, Islamic society is facing a cultural crisis. A crisis rooted in emotional dependence and self-destruction on the West. This situation has caused not only the West to colonize and exploit Islamic lands, but also to direct the thoughts and ideas of the Islamic youth in the desired direction. After identifying the crisis and its etiology, the Imam introduces his ideal society.