The current study aimed at predicting the need for achievement and responsibility among students based on their perceived competence and novelty-seeking. The population consisted of all the 987 students of Islamic Azad University in Gachsaran, Iran, and, based on Cochrane’s formula, a sample of 350 students was assessed using random cluster sampling. The study was practical and used a correlational design. The measures comprised the Herman’s Achievement Motivation Test, the Responsibility Questionnaire, the Perceived Competence Scale, the Conner-Davidson Resilience Scale, and the Cloninger’s Temperament and Character Inventory. Data from Pearson’s correlation coefficients and multivariable regression analyses showed that perceived competence and novelty-seeking could both meaningfully predict the need for achievement. Novelty-seeking was also a meaningful predictor of responsibility. However, perceived competence did not predict responsibility. The independent variables also, directly and indirectly, predicted the level of responsibility through the need for achievement, novelty-seeking, and perceived competence. Keywords: Need for achievement; Novelty-seeking; Perceived competence; Responsibility.