The current research was conducted with the aim of providing a model of international strategic business renewal in the country's pharmaceutical industry in a combined manner in two qualitative and quantitative phases. In the first phase, the research data was obtained from in-depth and semi-structured interviews with 18 subject matter experts, including entrepreneurs, managers, and senior experts in the pharmaceutical industry in Tehran province, which was based on purposeful sampling dependent on the selection criteria and until reaching the theoretical saturation of this process continued. The validity of the research data was checked and confirmed by going back to the participants and external auditors. Data analysis was done based on the Strauss and Corbin model in the form of open, axial, and selective coding in the Atlas TI8 software. The results of the research showed that entrepreneurial, organizational, managerial, environmental, marketing, international strategy, lean supply chain, social component, organizational performance, and financial performance components are important in designing the international strategic renewal model of pharmaceutical industry businesses. In the second phase of the research, according to the managers and experts of the Ministry of Privacy, there were 681 elites of the Ministry of Privacy, of which 248 research samples were identified using Morgan's sample size table; The tool for collecting information in this section was a researcher-made questionnaire in a five-point Likert spectrum; In order to estimate the validity of the questionnaire, content validity was used using the CVR method and confirmatory factor analysis; Also, the reliability of the tool was estimated to be higher than 0.7 through Cronbach's alpha. The results showed that causal conditions with (0.39), contextual conditions with (0.55), and intervening conditions with (0.34) have an effect on strategies, and strategies have an effect on outcomes with (0.85).
