The purpose of the present research is to examine the role of factors related to jihadi management and organizational spirituality in Sepah Bank employees in the southeastern region of the country and to present a favorable model. The present study is descriptive and correlational, and has been done by survey method. The statistical population of the study included all employees of Sepah Bank in the southeast region, and sampling has been done by the two-stage cluster method in order to analyze the data by descriptive and inferential statistics (correlation tests and structural equation modeling), and SPSS software was used. In this study, in order to collect data, a researcher-made questionnaire of factors related to jihadi management and an organizational spirituality questionnaire based on the Likert 5-item spectrum were applied. To measure validity, using Cronbach's alpha, the reliability value to raise a question of factors related to jihadi management was 0.931 and organizational spirituality was 0.981. In the present study, the significance level is considered 0.05. The findings showed that the model of explaining jihadi management based on organizational spirituality based on the following: increased organizational spirituality; reduction of opportunism; service spirit and responsibility; providing better services to customers; and ultimately the realization of organizational spirituality.