Home businesses play a positive role in economic growth and development. Therefore, the development of the capabilities of these businesses is an important issue in economic success. The purpose of this research was to investigate the impact of entrepreneurial knowledge on the structure and performance of home businesses. In this research, the indirect effect of the structure of home businesses on the performance of these types of businesses has been investigated. The data used in the analysis of this study were collected from 139home business owners using a questionnaire. Data analysis was done using structural equation modeling method with PLS approach and questionnaire constructs show good validity and reliability. Previous knowledge of home business owners has a positive (β=0.392) and significant (T=2.289, >1.96) effect on business structure performance. Therefore, the first research hypothesis is supported. Previous knowledge of home business owners has a positive (β=0.597) and significant (T=6.310, >1.96) effect on the performance structure of home businesses. And therefore, the second hypothesis of the research is supported. The structure of home businesses has a positive (β=0.4) and significant (T=2.124, >1.96) effect on business performance. And therefore, the third hypothesis of the research is also supported.