Timurid era in Iran is equivalent to starting the Renaissance. Black Death plague epidemic that is to say, at this time has happened. In one and a half-century Timurid rule, several large outbreaks of plague in Iran has emerged. The adverse effects of changes in population structure caused many historians point out these conditions in their works.
The literature review shows that, unlike physicians, historians of the time, they did not differentiate between the plague and cholera, and sometimes in their writings used the two diseases as equivalent. A study in Time and place of the epidemics shows that diseases have been traveling along the Silk Road route, and especially in northern Iran, from east toward west.