سعید نعیمی

Purpose: Diabetes mellitus is the most common metabolic problem worldwide, which is associated with hyperglycemia and structural and functional disorders of the nervous system. The aim of the present study was to investigate the effect of endurance training on serum glucose levels, weight changes and Like Growth Factor 1 (IGF-1) protein expression in the hippocampus of diabetic rats. Method: For this study, the samples included 48 male Wistar rats (8 weeks old), which were divided into 4 groups: control (C), the diabetes control (DC), diabetes-training (DT) and exercise (T). In order to induce diabetes, streptozotocin injection was used. 5 sessions per week of endurance activity were performed for 6 weeks. 48 hours after the completion of the exercise program, hippocampal tissue was dissected and extracted. ELISA method and one-way variance test were used to analyze the data. Resalts: Based on the results, serum glucose levels decreased after six weeks of endurance training (p=0.001). The amount of IGF-1 in group DC was significantly lower compared to all groups DT, T, and C (P≤0.05). But the DT group had no significant difference with the C and T groups (P=0.210 and P=0.226, respectively). On the other hand, the amount of IGF-1 in group T was only significantly different from group D (P=0.001). The correlation between blood glucose and IGF-1 was significant (p=0.001, r=0.820). Conclusion: Diabetes reduces IGF-1 and hyperglycemia, but exercise moderates the effect of diabetes on IGF-1. Considering the appropriate duration of training and the correlation of this protein with blood glucose, maybe endurance training can reduce the negative effect of diabetes.

Purpose: Osteoporosis is a decrease in bone density among older adults that can cause painful fractures and disability. One of the most important effective non-pharmacological interventions is having appropriate and continuous physical activity.  The aim of this study was to investigate the relationship between serum calcium and alkaline phosphatase with femur bone mineral density in active and inactive men. Method: This study was semi-experimental. 35 active and 35 inactive elderly men aged 65 to 80 years with medical records were selected. Anthropometric characteristics, serum calcium and alkaline phosphatase of subjects were used as effective indicators of osteoporosis. Pearson's correlation coefficient was used to find the relationship between femur mineral density and serum calcium and alkaline phosphatase, data analysis was done using SPSS version 26 Software. Results: The results of this research showed that in both groups of active and inactive men, there was a significant relationship between serum calcium and alkaline phosphatase and femur mineral density (P≤0.05). No significant relationship was found between the height index and mineral density of the femur (P≥0.05). Conclusions: In general, the results show that there is a significant relationship between bone density and weight, age, calcium, phosphorus, and serum alkaline phosphatase of all subjects, and the effect of exercise on other bone density indicators can be investigated.