Aspartate Aminotransferase

Purpose: Creatine is the most important and commonly used supplement in athletes. The purpose of this study was to investigate the simultaneous effect of moderate altitude and short-term Creatine supplementation on musculoskeletal damage indicators in male climbers. Method: 16 male hikers with at least 2 years of hiking experience selected. Subjects (age 30.6±6.3 yrs.), (height 178.3±6/4 cm), (weight 77.6±11.25kg) were randomly divided into experimental (Creatine supplement) and control groups (placebo). The experimental group consumed 20 gr/day of the supplement for 5 days, while the control group received a placebo. The first blood samples were taken before the hiking session at the location of program. Hiking program consisted of ascending to Tochal peak at an altitude of 3961m. The second blood samples were taken after returning from the peak at an altitude of 3750 meters. The results were analyzed by SPSS software using independent t-test and K-S test with a significant coefficient of 0.05. Results: The results showed that there was a significant difference between LDH and AST enzyme levels in post-test compared to pre-test in both AST (P = 0.13) and ALT (P = 0.001) levels Control group. Also, climbing to 4000 m altitude with Creatine supplementation had no significant effect on LDH (P = 0.78) and AST (P = 0.86) levels between groups. Conclusions: The results showed that changes in muscle damage enzymes are independent of Creatine supplementation.

Purpose: Creatine is the most important and commonly used supplement in athletes. The purpose of this study was to investigate the simultaneous effect of moderate altitude and short-term Creatine supplementation on musculoskeletal damage indicators in male climbers. Method: 16 male hikers with at least 2 years of hiking experience selected. Subjects (age 30.6±6.3 yrs.), (height 178.3±6/4 cm), (weight 77.6±11.25kg) were randomly divided into experimental (Creatine supplement) and control groups (placebo). The experimental group consumed 20 gr/day of the supplement for 5 days, while the control group received a placebo. The first blood samples were taken before the hiking session at the location of program. Hiking program consisted of ascending to Tochal peak at an altitude of 3961m. The second blood samples were taken after returning from the peak at an altitude of 3750 meters. The results were analyzed by SPSS software using independent t-test and K-S test with a significant coefficient of 0.05. Results: The results showed that there was a significant difference between LDH and AST enzyme levels in post-test compared to pre-test in both AST (P = 0.13) and ALT (P = 0.001) levels Control group. Also, climbing to 4000 m altitude with Creatine supplementation had no significant effect on LDH (P = 0.78) and AST (P = 0.86) levels between groups. Conclusions: The results showed that changes in muscle damage enzymes are independent of Creatine supplementation.

Purpose: The activity of plasma liver enzymes is intensified under the influence of sports activities, which is affected by the duration, intensity, type and method of training. The purpose of this study was to investigate the effect of a special endurance training session on the activity of serum alkaline phosphatase and aspartate aminotransferase liver enzymes in inactive young men. Methods: In this semi-experimental study, 16 young inactive men were purposefully selected and examined in two groups (experimental and control). The experimental group performed Bruce's protocol after preliminary warm-up. Blood samples were collected before the test, immediately after the test, 24 hours and 48 hours after the test from both groups at the same time, and the amount of serum ALP (Alkaline Phosphatase) and AST (Aspartate Transaminase) enzymes were measured using an Auto analyzer. Statistical analysis of the data, independent T-test was used to compare the results of two groups and Bonferroni's post hoc test was used to determine the difference between different stages of sampling with a minimum significance level (P≥0.05). Results: The results of the independent T-test in the comparison between the groups showed that there is a significant difference between the two groups in the amount of ALP enzyme in the time intervals immediately after the activity (P≥0.020), but in the time intervals of 24 (P≥0.177) and 48 hours (P≥0.136), there is no significant difference between the two groups after the activity. The results of the independent T test did not show any significant changes in the amount of AST enzyme in any of the time intervals in the comparison between groups. Conclusion: Fatigue-inducing sports activity leads to an increase in the amount of enzymes, ALP, this increase can be a sign of damage to liver cells or heart muscle. Considering the role of recovery in liver damage, it seems that by considering enough rest time, it is possible to help improve the adaptation process while preventing the occurrence of muscle and liver damage