The general consensus on the invaluable contributions of audio-visual materials based on cognitive theory of multimedia learning (CTML) to enhancing the quality of language classes has turned them into indispensable tools which teachers utilize for more effective teaching of different language skills. The primary aim of this study was to explore the effect of audio visual aids on reading skill at university level. The secondary aim was to find out if this change in materials could have any impact on the motivation and attitudes of the students toward English learning. To this end, this quasi-experimental study adopted a pre-test post-test research method. A total of 256 General English university students were divided to experimental (n=184) and control (n=81) groups. The experimental group received audio-visual aids as the treatment while the control group was taught by a conventional text-based method, commonly practiced in General English classes at Tabriz University of Medical Sciences (TUMS). The reading section of preliminary English test (PET) and Gardner’s attitude and motivation test battery (AMTB) were used for data collection. The results of independent samples t-test and Mann-Whitney tests revealed that the students provided with audio-visual materials obtained greater reading outcomes and also showed more positive attitudes and higher motivation toward English learning. Thus, our research revealed that the higher productivity and livelihood of reading classes can be tangible even in the in the narrow space of a single university semester.