Introduction: The main purpose of this study was to represent a conceptual model about the attitude towards the drug abuse based on assertiveness, psychological hardiness and emotional regulation in addicts. Methodology: The used method in this research was on the study and library base. In this research was paid attention to literature and the background about the research varieties and then a conceptual model was represented. Results: The addiction prevalent have well known that by making positive attitude towards drug and the spread of wrong belief in society they can achieve a good and beneficial market. So one of the general reason of addiction problem is the danger of manner in drug abuse and positive attitude to it and its effect. Accordingly the investigation of the attitude role on drug is an essential point in predicting and remedy of the addiction. In this research the effective factor in positive or negative attitude towards drug and addiction such as assertiveness, psychological hardiness and emotional regulation were discussed. The results show that the attitude has a direct and indirect influence on addictive behavior. Conclusion: Therefore, according to the assertiveness, psychological hardiness and emotional regulation, it can be possible to predict the attitude towards drug in addicts. So considering the research findings in predicting the drug abuse, it can be helpful to teach the individual.