مطالب

Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine. Aim : The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer. Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P <0.05. Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups ( P <0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups ( P <0.05). Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.  

The coronavirus pandemic affected education enormously, and despite numerous previous efforts to achieve digitalization, virtual teaching revealed deficiencies in both the EFL teachers’ digital competence and in the peripheral use of Information and communication technologies (ICTs). This study focused on a sample group to analyze the relationship between the implementation of this model and the pre-pandemic digital approach in order to identify deficiencies that need to be strengthened to achieve increasingly effective integration of blended learning. A questionnaire was used to collect data from participating teachers in the areas of school digital strategy, digital competence, and teaching practice in blended learning. The data were analyzed through structural equation models, verifying the relation between variables and also according to specific training on ICTs. An active but insufficient effort on the part of the participants’ schools to promote digitalization was revealed. The implementation of blended learning has been favored more by the responsiveness of participating EFL teachers than by the provision of specific training on the part of schools, which lacked common guidelines from the public administration. These EFL teachers can respond to changes, but the schools’ support is essential for the successful implementation of blended learning, updating the approach of the digital strategy adopted so far.

Children need to start learning English from a very young age in this fast globalizing world. The knowledge of the English language can assist in providing several opportunities for them in the future. It is also essential to know how very young children acquire a foreign language and which content and activities should be selected for their age. This study aimed to observe and describe the procedure of the language development of very young children. Researchers employed a descriptive case study design to portray and assess foreign language learning of two three-year-old twins’ grammar acquisition, vocabulary gains, and fluency in the early years of life (3-4/5). Besides the methods firmly associated with qualitative study and case studies, there were four sources of data collection: observation, audio-video recordings, and diary records. The central unit of the twins’ language development analysis was their utterances. The findings supported using a naturalistic environment where very young children could be exposed to the English language informally in everyday contexts and activities. This research can share its findings with education communities and very young children’s teachers to promote a new professional development model for fostering language development in very young learners’ classrooms, assessments, and curricula.

With the global spread of English as the lingua franca for academic publishing, non-native researchers and university students are constantly facing linguistic barriers including insufficient vocabulary knowledge in writing for publication. This persistent need motivated the development of a good number of corpus-based word lists for frequently used academic and technical words in research articles across disciplines. Nevertheless, despite its importance in corpus-based study of language for word list development, replication research has received far less attention in this line of inquiry. The current study aimed to address this gap and replicated two published studies that investigated the use of academic vocabulary in applied linguistics research articles. To this end, research articles published from 2010 to 2020 in 20 well-known journals in the field were collected, and a corpus with around 48 million words was compiled and analyzed. The findings indicated that academic vocabulary accounted for 11.46% of the corpus, which is similar and close to the reported coverage of the AWL in replicated studies. However, regarding the frequently occurring academic and non-academic content words, the findings showed considerable variation with respect to the results reported earlier. In light of these findings, the study highlighted the importance of replication research to test the reliability of corpus-based vocabulary studies that developed field-specific academic word lists. Finally, the study developed an updated version for applied linguistics academic word list, that might be regarded as a resource and guide for the vocabulary learning component of the relevant EAP programs in the field.