محمدرحمان رحیمی

Background : Anti-inflammatory markers play a crucial role in chronic diseases.. Regular training is a valuable method to control inflammation. Aim: This meta-analysis aims to explore the impact of exercise training on anti-inflammatory indicators like IL-10 and IL-4. Martials and methods: Various databases, including PubMed, Cochrane, Embase, Web of Science, EBSCO, and Google Scholar, were systematically searched for randomized controlled trials from 2007 to 2023. Studies focusing on IL-10 and IL-4 indicators in individuals undergoing exercise training were selected. According to the study inclusion criteria, ultimately, 40 articles were finally selected as study samples for the meta-analysis. The meta-analysis was conducted using fixed and random effects models to analyze the effect sizes, taking into account factors such as age, gender, health status, type and duration of exercise, and BM.. Results: Aerobic training significantly increased IL-10 levels (p=0.00, 95% CI=0.267:0.723, ES=0.495), while the increase after resistance training was not significant (ES=0.295, 95% CI-0.020:0.610, p=0.067). Both aerobic training (ES=-282, 95% CI=-0.795:0.185, p=0.237) and resistance training (ES=0.227, 95% CI=-0.389:0.843, p=0.471) had no significant effect onIL-4 levels. Subgroup analysis revealed a significant increase in IL-10 associated withBMI subgroups (p=0.019), with the highest increase in BMI group 18 to 25 (p=0.001). Subgroup meta-analysis for IL-4 showed no significant differences between subgroups (p>0.05). Conclusion: Aerobic training was associated with a significant increase in IL-10 levels in healthy and unhealthy subjects, but aerobic and resistance training had no significant effect on IL-4 levels. Further randomized controlled studies are essential, especially focusing on resistance training and different training scenarios.

Background: Caffeine is widely recognized as a potent ergogenic aid commonly used to enhance exercise performance and recovery. However, individual responses to caffeine can vary significantly, a variability that might be explained by genetic differences.Aim: This study aimed to investigate the influence of the CYP1A2 rs762551 SNP on the effects of caffeine (CAF) consumption on growth hormone (GH) and testosterone (TS) levels response to resistance exercise (RE) in male athletes.Materials and Methods: Thirty resistance-trained men (mean age 21.72±4.06 years, weight 77.31±14.07 kg, height 179.31±5.08 cm) participated in a randomized, double-blind, placebo-controlled, crossover study. They consumed either CAF (6 mg/kg) or placebo (PL; 6 mg/kg maltodextrin) one hour before performing a RE protocol including three sets with 85% of 1RM and two-minute rest. CYP1A2 genotyping categorized participants as AA homozygous ("fast" metabolizers) or AC heterozygous ("slow" metabolizers). GH and TS levels were measured by ELISA methods.Results: Repeated measures ANOVA showed significant differences in GH levels across time (F=10.94, P=0.000), with significant time-group (F=4.3, P=0.019) and time-genotype-group interactions (F=3.83, P=0.024). One-way ANOVA indicated significant differences in GH levels between CAF and PL conditions in AA individuals, but not in AC/CC genotypes. For testosterone, significant effects of time (F=14.88, P=0.000) and time-group interaction (F=3.197, P=0.045) were observed. Post-RE CAF supplementation significantly increased serum GH and TS levels in AA individuals compared to PL. Both CAF and PL groups showed increased serum hormone concentrations post-exercise.Conclusion: In conclusion, the study demonstrated that caffeine consumption significantly increased serum levels of growth hormone and testosterone in individuals with the AA genotype of the CYP1A2 rs762551 SNP. These findings suggest that genetic variations play a role in the hormonal response to caffeine, which may have implications for exercise performance and recovery strategies.