عبدالرضا ناصرمقدسی

Objective: This study aimed to assess the effectiveness of Cognitive-Behavioral Stress Management (CBSM) on distress tolerance, pain perception, and interleukin-12 (IL-12) in patients with Multiple Sclerosis (MS). Method: The present study was a quasi-experimental design with pretest-posttest and follow-up with control group. The statistical population included all female patients with relapsing-remitting MS who had referred to Neuroscience and Rehabilitation Research Centers of Tehran University of Medical Sciences. 20 patients were selected by convenience sampling and were randomly assigned into experimental (10 patients) and control groups (10 patients). The experimental group received the CBSM. Participants completed scales. To measure IL-12, the Enzyme-Linked Immunosorbent Assay (ELISA) was used. The data were analyzed using multivariate analysis of covariance (MANCOVA) and Bonferroni post-hoc test. Results: CBSM increased the distress tolerance and components of pain perception (perceived influence of important people and doing daily affairs) (p <0.001) and it decreased pain severity and IL-12. Also, these changes remained stable during follow-up. Conclusions: CBSM is an effective to influence on distress tolerance, pain perception, and IL-12 in MS patients.

Objective: This research was conducted to study the role of sleep quality moderators in the relationship between depression and treatment compliance.   Method : The research design was descriptive and correlational, and the research population included all patients with multiple sclerosis living in Tehran. 229 subjects with Multiple Sclerosis were selected in a convenient method, and they were asked to answer Morinsky's treatment compliance, Petersburg sleep quality, and Beck's depression questionnaires using the pencil and paper method. Results : Evidence of the predictive role of depressive symptoms for poor adherence to treatment in patients with multiple sclerosis was found. In addition, evidence of the predictive role of sleep quality in treatment adherence was found, but its mediating role in the relationship between depression and treatment adherence was not found. Conclusion : The findings indicated the importance of depression symptoms and sleep quality in the treatment compliance of multiple sclerosis patients. Considering the importance of treatment compliance in the prognosis of the disease, it is suggested that doctors consider this issue to formulate treatment plans to target cognitive and emotional problems parallel to the main treatment of the disease and thereby increase treatment compliance.