Teaching English for Academic Purposes (EAP) courses is highly demanding for EAP teachers as they are faced with diverse pedagogical and administrative challenges in such courses. This study addressed the level of burnout among EAP teachers and variations in relation to their demographic and organizational characteristics. To this aim, a demographic questionnaire along with the Persian version of the Maslach Burnout Inventory (MBI) was administered to 276 EAP teachers from state universities in Iran. The results revealed that a considerable number of EAP teachers reported mid-levels of personal accomplishment. Moreover, variations in degree of burnout were found among EAP teachers in relation to marital status, age, years of experience in teaching EAP and content/general English courses, educational background, and the field and number of EAP courses taught. Also, EAP teachers with different demographic and organizational characteristics who were more susceptible to burnout were identified. Finally, implications for enhancing the working conditions of EAP teachers are presented.