Objective The aim of this study was to investigate the relationship between perceived social support and psychological resilience with quality of life in people with physical disabilities. Methods The research method was descriptive-correlational and the statistical population included all people with any physical disabilities between the ages of 15 to 65 years in the cities of Golestan province, 100 of whom were selected using available and non-random sampling method. And after obtaining consent, completed the relevant questionnaires. Also, in order to collect data, Phillips Social Support Questionnaire, Klohnen Self- Efficacy Scale and WHO Quality of Life Questionnaire were used, and to analyze the data, version 24 of SPSS software, Pearson correlation coefficient and multiple regression were used. Results Findings showed that there is a positive relationship between perceived social support and quality of life in people with physical disabilities. The higher the social support, the higher the quality of life, as well as between psychological resilience and quality. Conclusion There is a significant relationship between people's lives and physical disabilities in that people who showed higher psychological resilience had a higher quality of life.